（S）-噻吗洛尔半水合物的合成及表征

为了开发β受体阻断剂新药（S）-噻吗洛尔半水合物，采用3-吗啉-4-氯-1，2，5-噻二唑为起始原料，经水解反应得到中间体1（3-吗啉-4-羟基-1，2，5-噻二唑）。中间体1与R-环氧氯丙烷发生醚化反应，经后处理及重结晶得到中间体2 {（R）-4-［4-（环氧乙烷-2-基甲氧基）-1，2，5-噻二唑-3-基］吗啉}。中间体2经胺化反应、马来酸成盐及重结晶得到（S）-马来酸噻吗洛尔。（S）-马来酸噻吗洛尔经游离、纯水转晶得到符合药典标准的（S）-噻吗洛尔半水合物，总收率14.05%且e.e.值为99.66%。最终成品经IR、1H-NMR、13C-NMR、MS、TGA、DSC表征，并优化各步反应条件。结果表明:以三乙胺为醚化反应缚酸剂75 ℃反应最佳；以乙醇为胺化反应溶剂46 ℃反应16 h最佳；S-噻吗洛尔的转晶拆分以水作溶剂，比传统不对称合成工艺安全稳定，操作简单，适合工业化生产。     

Microstructural characterization of plasma sprayed Ln2Zr2O7 thermal barrier coatings by electron microscopy methods

The presented article characterized microstructural aspects of thermal barrier coatings (TBCs) analysis using methods of electron microscopy such as electron backscatter diffraction (EBSD), transmission/scanning electron microscopy (S/TEM), and TEM. The analyzed TBC system is based on gadolinium zirconate deposited by air plasma spraying method, and additionally, it was subjected to an oxidation test for 500 hr at a temperature of 1,100°C. Moreover, the morphological characterization of feedstock powder was showed. EBSD analysis revealed the inhomogeneity of feedstock materials in the form of complex phase composition. In the case of deposited coating, this method was used to characterize the crystallite size of zirconate coating and phase composition of thermally grown oxide zone. S/TEM and TEM analysis showed morphological details of this zone but not revealed such phase as perovskite oxide of GdAlO₃ type.     

面向技术问题的3D打印关键技术专利规避设计方法

在工程实践中,为了解决存在的技术问题,需要对现有产品进行创新设计,针对产品创新设计中普遍存在的专利规避需求,结合TRIZ建立了专利规避设计流程,包括规避问题的提出、规避对象的确定和规避设计;以FDM技术为例,对造成FDM技术成型精度低和打印速度慢的问题进行分析,并结合问题原因,专利检索到了在保证打印精度的前提下提高打印速度的技术方案,通过技术迁移,建立了迁移后的初始模型,并利用TRIZ中的功能裁剪进行了专利规避设计和侵权判定,可为企业及研究机构利用专利信息实施专利规避设计提供参考。     

物理化学课程的创新教学模式研究及其效果分析

物理化学课程创新教学模式是以学生学习为中心,吐故纳新,优化精选,以新颖或变化的教学方式进行教学。调查表明创新教学模式受到绝大多数学生的肯定和认可,有效地调动学生的积极性,提高了学生对物理化学的学习和探究兴趣,学生提问问题的广度和难度发生显著变化。该教学模式能够逐步提升学生的创新意识和创新能力。     

新形势下普通高校大学生行为管理模式研究

高校是培养人才的摇篮,肩负着科教兴国、人才强国两大历史性战略任务。由于社会环境的复杂化,人际关系的交错性,新时代的大学生行为状况给高校学生管理工作带来了新的挑战。针对新时期大学生行为特点,我们通过加强党建工作、强化学风建设、做好班级自主管理和深化社会服务四个方面工作进行分析,提出了全面引导、约束、规范和优化大学生的行为的建议和对策,从而有效解决新形势下普通高校学生管理工作的实际困难。     

Study on maximum power point tracking of photovoltaic array in irregular shadow

Traditional maximum power point tracking (MPPT) methods can hardly find global maximum power point (MPP) because output characteristics curve of photovoltaic (PV) array may have multi local maximum power points in irregular shadow, and thus easily fall into the local maximum power point. To address this drawback, Considering that sliding mode variable structure (SMVS) control strategy have such advantages as simple structure, fast response and strong robustness, and P&O method have the advantages of simple principle and convenient implementation, so a new algorithm combining SMVS control method and P&O method is proposed, besides, PI controller is applied to reduce system chattering caused by switching sliding surface. It is applied to MPPT control of PV array in irregular shadow to solve the problem of multi-peak optimization in partial shadow. In order to verity the rationality of the proposed algorithm, the experimental circuit is built, which achieves MPPT control by means of the proposed algorithm and P&O method. The experimental results show that compared with the traditional P&O algorithm, the proposed algorithm can fast track the global MPP, tracking speed increases by 60% and the relative error decreased by 20%. Moreover, the system becomes more stable near the MPP, the fluctuations of output power is greatly reduced, and thus make full use of solar energy.     

冷轧平整机机前甩尾轧制工艺的开发与应用

本文介绍了柳钢冷轧板带厂1550 mm单机架平整机机前甩尾轧制的工艺。改进前轧制每卷钢卷生产效率低,钢卷成材率低,改进后生产效率、成材率明显提高,部分规格的钢卷能实现带尾剪切长度为零。     

Improving CNC contouring accuracy by robust digital integral sliding mode control

Integral sliding mode control (ISMC) has been employed and shown to improve contouring accuracy in the presence of external disturbances and model uncertainties. An ISMC controller directly reduces the tracking errors of each individual axis, thereby reducing the overall contour errors indirectly. An ISMC controller drives the system dynamics back onto the sliding surface if there exists a deviation from the predefined surface. In the design of an ISMC controller, it is crucial to choose an appropriate sliding surface as this has a great impact on system performance and on chattering. In current approaches, the sliding surface is chosen largely based on a rule of thumb which is only applicable for systems with open-loop poles having imaginary parts. In this paper, an approach is presented to design the sliding surface using principles of robust digital control so that both the regulation and robustness requirements can be satisfied. The natural frequency of the dominant closed-loop poles is chosen such that the modulus of the output sensitivity function lies within the robustness bounds. Resonant pole-zero filters are then used to reshape the output sensitivity function in specific frequency regions. Experiments showed that when the modulus of the output sensitivity function is kept within the robustness bounds, chattering can be avoided and the contour errors resulting from vibrations can be reduced. The introduction of a resonant pole-zero filter also allowed the attenuation band to be expanded so that the low frequency components of the contour errors are attenuated.     

Validation of an integral sliding mode control for optimal control of a three blade variable speed variable pitch wind turbine

Reduction in cost of wind energy requires most efficient control technology which can able to extract optimum power from the wind. This paper mainly focuses on the control of variable speed variable pitch wind turbine (VSVPWT) for maximization of extracted power at below rated wind speed (region 2) and regulation of extracted power when operating at above rated wind speed (region 3). To extract maximum power at below rated wind speed torque control is used whereas to regulate rated power at above rated wind speed pitch control is used. In this paper a nonlinear control i.e. integral sliding mode control (ISMC) is proposed for region 2 whereas a conventional proportional–integral (PI) control is adapted for region 3 of a VSVPWT. The proposed controller is combined with modified Newton Raphson (MNR) wind speed estimator to estimate the wind speed. The stability of the proposed ISMC is analyzed using Lyapunov stability criterion and the control law is derived for region 2 which is also adapted for the transition period between region 2 and region 3 (region 2.5). The dynamic simulations are tested with nonlinear FAST (Fatigue, Aerodynamics, Structures, and Turbulence) wind turbine (WT). The simulation results of ISMC are presented and the control performance is compared with conventional SMC and existing controllers such as aerodynamic torque feed forward control (ATF) and Indirect speed control (ISC). It is seen that especially in region 2.5, ISMC gives better performance compared to all other controllers.